Hemoglobin Change and Sickle Cell Disease

 

Adapted by permission from Arnone, A.;Thillet, J. and Rosa, J. 1981 J. Biol. Chem., in press.

In 1927, Hahn and Gillespie showed that sickling of the red cells was related to the delivery of less oxygen. What could be the problem?

In 1940, Sherman, a medical student at Johns Hopkins, noted a change in deoxygenated red cells (they either are in a state WITH oxygen or WITHOUT), suggesting to others that low oxygen altered the structure of "certain molecules of the cell". He didn't know what within the cell it might be. (You might make a list of choices before "turning" the page.

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